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For all these reasons we aimed to optimize and validate moving average quality control (MA QC) procedures for the international normalized ratio (INR) and the activated partial thromboplastin time (aPTT) to enable real-time continuous quality control for these tests. Furthermore inherent to the practice of quality control measurements is its scheduled character. The analytical quality assurance of coagulation testing is complicated by the risk of applying non-commutable control materials and analytical drift related to reagent lot changes. Received: 10 March 2020 Accepted: 09 September 2020 Published: 30 October 2020. Keywords: Moving average quality assurance patient based real-time QC international normalized ratio (INR) activated partial thromboplastin time (aPTT) Furthermore, an otherwise undetected aPTT shift was detectable using MA QC. Finally, MA QC procedures were obtained that enabled detection of a ≥15% systematic error within a median of 27 test results (range 1–88 results) for INR and 22 test results (range 1–67 results) for aPTT.Ĭonclusions: MA QC procedures were obtained for INR and aPTT with relevant systematic error detection performance. Furthermore, when using the mean calculation for both INR and aPTT, truncation of higher results was required to enable detection of relevant error.
#Glims mips verification#
For aPTT when studying MA QC, a 2 second shift in aPTT results was noticed, which was not or not in the same amount detected by standard internal QC measurement and a aPTT verification procedure consisting of a 20 sample comparison study respectively. Results: Several MA QC procedures with various truncation limits and batch sizes were studied to select optimal MA QC.
#Glims mips software#
Optimization focused only on the mean calculation since only this calculation algorithm was supported by the laboratory software used to operate MA QC. Optimal MA QC was selected based on the overall systematic error detection properties.
#Glims mips generator#
The online MA Generator application ( was used to enable MA QC visualization, optimization and validation. Methods: Six months of historical INR and aPTT results were used as training dataset.
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GLIMS Genomics: A solution that covers the entire genetic / genomic spectrum and creates integrated digital workflows for conventional and molecular cytogenetics, tumour genetics, array CGH, MLPA, PCR, and DNA sequencing, as well as Next-generation sequencing.Background: The analytical quality assurance of coagulation testing is complicated by the risk of applying non-commutable control materials and analytical drift related to reagent lot changes. GLIMS Genomics combines the strengths of a mature LIMS for the routine laboratory areas with the special requirements in genomics, including the latest methods such as NGS. Our answer for human genetics is GLIMS Genomics. GLIMS Genomics – Leading-edge Laboratory Software for Human Genetics Electronic Requesting & Results Reporting.